Original Article

Porcine Dermal Collagen Prevents Seroma Formation After Mastectomy and Axillary Dissection in Rats


  • Cihan Ağalar
  • Ali İbrahim Sevinç
  • Anıl Aysal
  • Tufan Egeli
  • Özkan Süleyman Aksoy
  • Mehmet Ali Koçdor

Received Date: 31.05.2017 Accepted Date: 07.07.2017 Eur J Breast Health 2017;13(4):200-205


Seroma occurs as a result of accumulation lymphovascular liquid in the dead space forming after tissue dissection. It is the most common complication after breast surgery. Collagens are the common component of extracellular matrix and have an important role in wound healing. In this study, we aimed to investigate the efficiency of the Porcine Dermal Collagen in preventing Seroma.

Materials and methods:

Eighteen young female Wistar rats were used and divided into three groups. Mastectomy and axillary dissection were performed in each group. No other procedures were performed in Group 1 (Control group). Porcine dermal collagen was applied to 50% of the mastectomy field in Group 2 and to 100% of the mastectomy field in Group 3.


Seroma volume was significantly decreased in Group 3 in contrast to Groups 1 and 2 (p<0.001) and in Group 2 in contrast to Group 1 (p<0.001). Vascular proliferation, granulation tissue formation and congestion were significantly increased in Group 3 (p<0.05).


We conclude that the use of Porcine Dermal Collagen reduces the formation of seroma in the model of experimental mastectomy and axillary dissection. As the amount of Porcine Dermal Collagen applied increases the formation of seroma reduces.

Keywords: Axillary Dissection, breast, mastectomy, porcine dermal collagen, seroma